Cavin家族蛋白在糖尿病胰島素抵抗的研究進展
首發時間:2018-04-25
摘要:2型糖尿病是由多病因引起的以慢性高血糖為特征的、以胰島素抵抗伴胰島素分泌不足為主要病理生理機制的代謝性疾病。糖尿病及其并發癥的發生、發展過程中,表現出葡萄糖代謝、脂肪、蛋白質代謝紊亂、胰島素抵抗、大血管及微血管進行性病變等病理過程,胰島素抵抗是重要的病理機制。微囊位于脊椎動物多種細胞表面,介導胰島素受體從而參與脂肪、葡萄糖轉運和胰島素抵抗相關信號轉導。研究Cavin家族蛋白對微囊結構數量和功能的調節作用,通過胰島素受體及受體后信號通路對糖尿病胰島素抵抗過程起的作用及可能的機制,旨在為研究胰島素抵抗提供新思路。
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Research progress on the effects and mechanisms of Cavin family on diabetic insulin resistence
Abstract:Type 2 diabetes is a metabolic disease characterized by multiple causes of chronic hyperglycemia, which is characterized mainly by insulin resistance with insulin progressive hyposecretion to mainly by insulin hyposecretion with insulin resistence. During the initiation and development of diabetes and its complications, insulin resistance is an important pathological mechanism in the pathological process of glucose metabolism, lipid, protein metabolism disorder, insulin resistance, large blood vessel and microvascular progressive damage. Caveolae is located on many cell surfaces of vertebrates, mediating insulin receptor and participating in signal transduction related to fat, glucose transport and insulin resistance. In order to provide new ideas for the insulin resistance, the role and possible mechanism of Cavin family proteins on the regulation for structure, number and function throuhg the role of insulin receptor and post receptor signaling pathway in insulin resistance are studied.
Keywords: insulin resistence caveolae;insulin receptor;lipid droplet
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Cavin家族蛋白在糖尿病胰島素抵抗的研究進展
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