結直腸癌患者腸道菌群特征研究
首發時間:2023-05-12
摘要:結直腸癌是十分常見且具有高致死率的癌癥。結直腸癌的發生與腸道菌群有著密不可分的關系。目的:分析結直腸癌患者腸道菌群的特征,探索診斷結直腸癌的菌群潛在標志物。方法:對腸道的16S rRNA進行測序,對比結直腸癌患者與健康人腸道菌群的構成改變。結果:結直腸癌患者腸道菌群β多樣性與健康人群有顯著差異。結直腸癌患者腸道擬桿菌屬、普雷沃屬菌屬豐度發生改變。埃希菌、γ-變形菌、變形菌、腸桿菌屬、腸桿菌目、細菌門可作為結直腸癌潛在的菌群潛在標志物。
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Characteristics of intestinal flora in patients with colorectal cancer
Abstract:Colorectal cancer is a very common cancer with high mortality. The occurrence of colorectal cancer is closely related to intestinal flora. Objective: To analyze the composition of intestinal flora in patients with colorectal cancer, and to find out the biomarkers for the diagnosis of colorectal cancer. Methods: Intestinal 16S rRNA was sequenced to compare the composition of intestinal flora between colorectal cancer patients and healthy people. Results: The diversity of intestinal flora β in colorectal cancer patients was significantly different from that in healthy people. The abundance of Bacteroides and Prevoides in colorectal cancer patients was changed. Escherichia, gamma-Proteus, Proteus, Enterobacteriaceae, Enterobacteriaceae and Bacteria can be used as potential markers of colorectal cancer.
Keywords: colorectal cancer Intestinal flora 16S rRNA
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